Proton-pump inhibitors (PPIs) are a class of medications that reduce stomach acid production by blocking the enzyme responsible for acid secretion in the stomach lining. They are commonly prescribed to treat conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. PPIs provide long-lasting relief from acid-related disorders and are more effective than other acid-reducing medications like H2 blockers. However, long-term use of PPIs may lead to side effects such as nutrient deficiencies, an increased risk of infections, and bone fractures. It is essential to use them under medical supervision to avoid potential complications.